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Association between serum Fe levels and obesity: a meta-analysis
Lijuan Yang1, Yi Chen2, Mi Lu3
1Department of Physiology, Bengbu Medical College, Bengbu, Anhui 233030.. 1983helianping@163.com.
Nutricion Hospitalaria
|June 5, 2015
Summary
Individuals with obesity tend to have lower serum iron (Fe) levels compared to healthy individuals. This meta-analysis suggests iron supplementation may help prevent obesity.
Area of Science:
- Nutritional Science
- Metabolic Disorders
- Public Health
Background:
- Obesity is a complex metabolic disorder with significant public health implications.
- Iron (Fe) is an essential mineral involved in numerous physiological processes, including energy metabolism.
- The relationship between serum Fe levels and obesity requires further clarification.
Purpose of the Study:
- To investigate the association between serum Fe levels and obesity.
- To synthesize existing evidence using a meta-analysis approach.
Main Methods:
- Systematic literature search of PubMed and Chinese National Knowledge Infrastructure (CNKI) for studies published between 2006 and 2014.
- Inclusion of 6 eligible case-control studies involving 934 subjects.
- Data collection and analysis using Review Manage software.
Main Results:
- Pooled analysis revealed significantly lower serum Fe levels in subjects with obesity compared to healthy controls.
- Standardized Mean Difference (SMD) = -0.738, 95% Confidence Interval (CI) = (-1.228, -0.247).
Conclusions:
- A significant inverse association exists between serum Fe levels and obesity.
- Dietary iron supplementation may be a potential strategy for obesity prevention.
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