Related Experiment Video
Updated: Apr 11, 2026
08:31
Candida albicans Biofilm Development on Medically-relevant Foreign Bodies in a Mouse Subcutaneous Model Followed by Bioluminescence Imaging
Published on: January 27, 2015
13.7K
[Endogenous Candida lens abscess in a premature infant]
Achim Fieß1, J Bauer2, C Schindel3
1Augenklinik des Klinikums Wiesbaden, Dr. Horst-Schmidt-Kliniken, Ludwig-Erhard-Straße 100, 65199, Wiesbaden, Deutschland. Achim.Fiess@hsk-wiesbaden.de.
Summary
This case report details a rare Candida lens abscess in a premature infant. Delayed abscess formation is possible in preterm infants due to pathogen dissemination, even after initial sepsis treatment.
Area of Science:
- Ophthalmology
- Neonatology
- Infectious Diseases
Background:
- Describes an extremely rare case of Candida lens abscess.
- Focuses on a premature infant born at 24 weeks gestational age.
- The infant had a history of successfully treated Candida sepsis.
Observation:
- Patient presented at 6 months with greyish pupillary alterations.
- Examination revealed a grey pupillary membrane and a swollen lens.
- A lensectomy was performed, and Candida albicans was identified.
Findings:
- Identified Candida albicans as the causative agent.
- Confirmed a delayed abscess formation within the lens.
- Demonstrated the possibility of pathogen dissemination into the lens.
Implications:
- Highlights the risk of delayed intraocular infections in preterm infants.
- Suggests that the lens may become inaccessible to systemic treatment after vascular regression.
- Emphasizes the need for vigilance in diagnosing and managing fungal endophthalmitis in neonates.
Related Concept Videos
01:25Glaucoma: Overview
1.7K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.7K
01:28Development of the Oral Microbiota
39
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
39
01:28Angle Closure Glaucoma: Treatment
1.7K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.7K
01:22Microbiome of the Eye
58
The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
58