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Updated: Apr 11, 2026
A Polyaniline-based Sensor of Nucleic Acids
Published on: November 1, 2016
An anionic conjugated polymer as a multi-action sensor for the sensitive detection of Cu(2+) and PPi, real-time ALP
Akhtar H Malik1, Sameer Hussain, Arvin Sain Tanwar
1Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati-781039, India. pki@iitg.ernet.in.
Abstract:
A Cu(2+) ensemble polyfluorene derivative, poly[5,5'-(((9H-fluorene-9,9-diyl)bis(hexane-6,1-diyl))bis(oxy))diisophthalate] sodium salt (PFT), displays unprecedented selectivity for PPi (LOD = 2.26 ppb) in aqueous solution as well as in random urine samples at physiological pH vis-a-vis monitoring ALP activity. Furthermore, intracellular imaging of Cu(2+) and PPi in mouse macrophage (J774A.1) and human breast cancer cells (MDA-MB231) was achieved to confirm the viability of PFT in biological systems.
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