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Intermediate Strain Rate Material Characterization with Digital Image Correlation
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Reference Materials: Significance, General Requirements, and Demand.

Anna Kiełbasa1, Renata Gadzała-Kopciuch1, Bogusław Buszewski1

  • 1a Department of Environmental Chemistry and Bioanalytics , Nicolaus Copernicus University , Toruń , Poland.

Critical Reviews in Analytical Chemistry
|June 5, 2015
PubMed
Summary

New scientific fields require new reference materials, especially complex tissue certified reference materials (CRMs). Developing stable and homogeneous CRMs is challenging but crucial for accurate analysis in proteomics, metabolomics, and genomics.

Keywords:
Biological matricescertificationcertified reference materialhomogeneitymetabolomicsuncertainty

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Area of Science:

  • Analytical Chemistry
  • Biochemistry
  • Genomics
  • Metabolomics
  • Proteomics

Background:

  • Reference materials are essential for accurate analytical measurements and quality control.
  • Emerging scientific disciplines like proteomics, metabolomics, and genomics demand novel reference materials.
  • The production of complex biological matrices, such as tissues, presents significant challenges in homogeneity and stability.

Purpose of the Study:

  • To highlight the critical need for developing new reference materials.
  • To emphasize the challenges in producing complex tissue certified reference materials (CRMs).
  • To advocate for an increased number of CRMs to support scientific research and toxicological analysis.

Main Methods:

  • The abstract does not specify methods, focusing on the need and challenges.
  • Discussion of the complexity in preparing and certifying tissue reference materials.
  • Emphasis on the importance of homogeneity and stability in reference material production.

Main Results:

  • The abstract does not present specific results but outlines challenges.
  • Tissue CRMs are among the most complex and time-consuming to prepare.
  • Accurate determination of trace substances in tissues requires high-quality reference materials.

Conclusions:

  • Continuous development and increased availability of CRMs are necessary.
  • Addressing the challenges in CRM production is vital for advancing scientific disciplines.
  • CRMs are indispensable tools for chemists, analysts, and toxicologists.