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MEIC Evaluation of Acute Systemic Toxicity: Part VI. The Prediction of Human Toxicity by Rodent LD50 Values and

B Ekwall1, F A Barile2, A Castano3

  • 1CTLU, Stånga, Sweden.

Alternatives to Laboratory Animals : ATLA
|June 5, 2015
PubMed
Abstract

No abstract available in PubMed .

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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