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Click-engineered, bioresponsive, drug-loaded PEG spheres
Heng Pho Yap1, Angus P R Johnston1, Georgina K Such1
1Centre for Nanoscience and Nanotechnology (CNST) Department of Chemical and Biomolecular Engineering The University of Melbourne Victoria, 3010 (Australia).
Advanced Materials (Deerfield Beach, Fla.)
|June 5, 2015
Abstract:
A click-chemistry approach to synthesize bioresponsive poly(ethylene glycol acrylate) particles is described. The particles are loaded with a model anticancer drug (doxorubicin, DOX), and undergo simultaneous particle deconstruction and DOX release upon specific activation by the simulated environment of the cellular cytoplasm.