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Updated: Apr 11, 2026

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody
Published on: May 16, 2020
Ofatumumab in the treatment of non-Hodgkin's lymphomas
Lionel Karlin1, Bertrand Coiffier
1Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Hematology Department , 165, Chemin du Grand Revoyet 69495 Pierre-Benite , France +33 478864301 ; +33 478864355 ; bertrand.coiffier@univ-lyon1.fr.
Introduction:
Ofatumumab is a second-generation humanized monoclonal antibody targeting CD20 registered for the treatment of patients with relapsing/refractory chronic lymphocytic leukemia. This review will describe the activity of ofatumumab in patients with CD20 B-cell lymphomas.
Areas Covered:
A review of all manuscript published on ofatumumab activity in B-cell lymphomas is presented with conclusions on the future use of this antibody in these patients.
Expert Opinion:
Ofatumumab activity is low in indolent or aggressive B-cell lymphomas. The future of this drug is challenged by new monoclonal antibodies and new targeted drugs.
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