Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

1.1K
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
1.1K
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.6K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.6K
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

710
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
710
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

1.5K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.5K
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

948
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
948
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

660
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
660

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Similar androgen receptor expression in male and female AML.

Blood advances·2026
Same author

Adaptation to cystine limitation stress confers a targetable lipid metabolism vulnerability in pancreatic ductal adenocarcinoma.

Nature communications·2025
Same author

Redox Modulation of Erythropoiesis by Selenoproteins.

Biological trace element research·2025
Same author

Sequestration of plant defenses by spotted lanternfly (Lycorma delicatula) and effects on avian predators.

Journal of chemical ecology·2025
Same author

<i>Trsp</i> is required by regulatory T cells to prevent lethal autoimmunity in mice.

bioRxiv : the preprint server for biology·2025
Same author

Androgen receptor signaling as a new target for intervention in acute myeloid leukemia.

Blood advances·2025
Same journal

MYO5B Deficiency Is Associated with Altered MUC13 Localization and DMBT1 Accumulation in Intestinal Epithelial Cells.

American journal of physiology. Gastrointestinal and liver physiology·2026
Same journal

Microbiota dysbiosis and mucosal hyperinnervation contribute to intestinal hyperalgesia in a mouse model of post-infectious irritable bowel syndrome.

American journal of physiology. Gastrointestinal and liver physiology·2026
Same journal

Roux-en-Y gastric bypass alters microbial circadian rhythms with links to metabolic improvement.

American journal of physiology. Gastrointestinal and liver physiology·2026
Same journal

Therapeutic zinc targets dysregulated GC-C signaling and restores ileal defects in a preclinical model of familial diarrheal disease.

American journal of physiology. Gastrointestinal and liver physiology·2026
Same journal

Epithelial fucosylation regulates intestinal stem cell differentiation.

American journal of physiology. Gastrointestinal and liver physiology·2026
Same journal

Claims regarding the fidelity of extracellular electrical recording from gastrointestinal muscles not validated suitably.

American journal of physiology. Gastrointestinal and liver physiology·2026
See all related articles

Related Experiment Video

Updated: Apr 11, 2026

Investigating Intestinal Inflammation in DSS-induced Model of IBD
08:43

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

69.4K

Selenium and inflammatory bowel disease.

Avinash K Kudva1, Ashley E Shay1, K Sandeep Prabhu2

  • 1Center for Molecular Immunology and Infectious Disease and Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania.

American Journal of Physiology. Gastrointestinal and Liver Physiology
|June 6, 2015
PubMed
Summary
This summary is machine-generated.

Dietary selenium, incorporated into selenoproteins, is vital for immune function and resolving gut inflammation. This review explores how selenium influences macrophages to combat inflammatory bowel disease (IBD) and restore gut health.

Keywords:
cyclooxygenaseglutathione peroxidaseprostaglandinselenoproteins

More Related Videos

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
09:04

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

49.4K
Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
09:01

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Published on: March 10, 2015

10.6K

Related Experiment Videos

Last Updated: Apr 11, 2026

Investigating Intestinal Inflammation in DSS-induced Model of IBD
08:43

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

69.4K
DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
09:04

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

49.4K
Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
09:01

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Published on: March 10, 2015

10.6K

Area of Science:

  • Nutritional Immunology
  • Gastroenterology
  • Molecular Biology

Background:

  • Dietary selenium is crucial for immune function, incorporated into selenoproteins.
  • Inflammatory bowel disease (IBD) involves complex gut inflammation with unknown causes.
  • Epidemiological studies suggest a link between low selenium levels and increased IBD risk.

Purpose of the Study:

  • To review the role of selenoproteins in IBD pathophysiology.
  • To elucidate mechanisms by which selenium modulates gut inflammation.
  • To highlight selenium's potential in restoring gut homeostasis.

Main Methods:

  • Literature review of IBD pathophysiology and selenium's role.
  • Focus on selenoproteins and macrophage function in inflammation.
  • Analysis of molecular pathways regulating inflammation and gut repair.

Main Results:

  • Selenoproteins modulate inflammatory pathways, with macrophages playing a key role.
  • Altered selenoprotein expression in macrophages shifts them to an anti-inflammatory phenotype.
  • Selenium influences cytokines, metabolites, and transcription factors (NF-κB, PPAR-γ) to resolve inflammation.

Conclusions:

  • Selenium influences macrophage phenotype plasticity, crucial for resolving gut inflammation.
  • Selenium-dependent mechanisms contribute to restoring epithelial barrier integrity and gut homeostasis.
  • The intestinal microbiome interacts with selenium to mitigate gut injury in IBD.