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Published on: October 27, 2020
Effect of transforming growth factor-β1 869C/T polymorphism and radiation pneumonitis
Yingtian Wang1, Xingguang Wang2, Xiyan Wang3
1Department of Respiratory Medicine, Dongying People's Hospital of Shandong Province Dongying 257091, Shandong, China.
Background:
The Transforming growth factor-β1 (TGFβ1) 869C/T polymorphism was associated with radiation pneumonitis (RP) susceptibility. However, the results remained controversial. Thus, a meta-analysis was conducted.
Methods:
Relevant studies were systematically searched by using the NCBI, Medline, Web of Science and Embase databases. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models.
Results:
There was a significant association between TGFβ1 869C/T polymorphism and RP susceptibility (OR=1.77; 95% CI, 1.27-2.47; P=0.0007).
Conclusion:
This study suggested that TGFβ1 869C/T polymorphism was a risk factor of RP.
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