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Postmenopausal Meigs' Syndrome in Elevated CA-125: A Case Report.
Jung-Woo Park1, Jong Woon Bae1
1Department of Obstetrics and Gynecology, Dong-A University, College of Medicine, Busan, Korea.
Journal of Menopausal Medicine
|June 6, 2015
Summary
Meigs' syndrome, a rare benign ovarian tumor, can mimic malignancy with ascites, pleural effusion, and elevated cancer antigen 125 (CA-125). Surgical removal resolved symptoms and normalized CA-125 levels, highlighting its importance in differential diagnosis.
Area of Science:
- Gynecology
- Oncology
Background:
- Meigs' syndrome is characterized by a benign ovarian tumor, ascites, and pleural effusion.
- Elevated cancer antigen 125 (CA-125) is uncommon in Meigs' syndrome, often suggesting malignancy.
Observation:
- A 61-year-old woman presented with dyspnea, a pelvic mass, ascites, and pleural effusion.
- Initial investigations revealed no malignancy in pleural fluid, but a high CA-125 level (347 IU/mL).
Findings:
- Histological examination confirmed an ovarian thecoma, a benign tumor.
- Post-resection, the patient's symptoms resolved, and CA-125 levels normalized to 19 IU/mL.
- The patient remained asymptomatic during a 12-month follow-up.
Implications:
- Meigs' syndrome should be considered in postmenopausal women presenting with ovarian tumors, ascites, pleural effusion, and elevated CA-125.
- This case underscores the importance of including benign conditions in the differential diagnosis of suspected ovarian malignancies.
