Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Typing01:10

Blood Typing

4.8K
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
4.8K
Blood Types02:20

Blood Types

24.7K
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
24.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dissecting the disconnect between circuit activation and dominant adaptive evolution in cytoplasmic phage-assisted continuous evolution (PACE) of an EGFR nanobody.

Frontiers in bioengineering and biotechnology·2026
Same author

Structure, Interactions, and Assembly of Membrane-Active Antimicrobial Polypeptides.

Chemical reviews·2026
Same author

Modulating 3D-printability with nanocellulose hydrogels.

Journal of colloid and interface science·2026
Same author

Single-Step Grafting of a Thermoresponsive RAFT Polymer from Nanocellulose by Radical Decarboxylation.

ACS polymers Au·2026
Same author

An antagomiR-loaded β-peptide hydrogel promotes functional recovery in mice post-ischaemic stroke.

Biomaterials advances·2026
Same author

Designing Functional Membranes with Tunable PDA/PEI Coatings for Enzyme Entrapment.

ACS applied materials & interfaces·2026
Same journal

Recent developments of textile-based triboelectric nanogenerators for smart sports applications.

Biosensors & bioelectronics·2026
Same journal

One-Tube RPA-CRISPR-Cas13a assay with rational design for single-molecule detection of waterborne viruses in drinking water treatment.

Biosensors & bioelectronics·2026
Same journal

AI-driven photophysics-aware design of fluorescent probes with applications in α-synuclein biosensing and inhibitor screening.

Biosensors & bioelectronics·2026
Same journal

Three-dimensional helical integration of high-density linear microelectrode arrays and their cross-tissue applications.

Biosensors & bioelectronics·2026
Same journal

Integration of electrochemical sensors in organ-on-a-chip microfluidic platforms: Advances and perspectives.

Biosensors & bioelectronics·2026
Same journal

DNN-PURE: A deep neural network approach to paper-based urea sensing.

Biosensors & bioelectronics·2026
See all related articles

Related Experiment Video

Updated: Apr 11, 2026

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
06:12

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Published on: March 17, 2023

2.1K

Quantitative blood group typing using surface plasmon resonance.

Whui Lyn Then1, Marie-Isabel Aguilar2, Gil Garnier1

  • 1Bioresource Research Institute of Australia (BioPRIA), Australian Pulp and Paper Institute (APPI), Department of Chemical Engineering, Faculty of Engineering, Monash University, Clayton, VIC 3800, Australia.

Biosensors & Bioelectronics
|June 7, 2015
PubMed
Summary
This summary is machine-generated.

This study presents a novel, regenerable biosensing platform for accurate blood group typing using surface plasmon resonance (SPR). The system quantifies red blood cell interactions with antibodies, offering a reliable alternative to subjective current methods.

Keywords:
Blood group typingDiagnosticIgG antibodyRed blood cells (RBCs)Rh phenotypeSurface plasmon resonance

More Related Videos

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum
09:23

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum

Published on: December 13, 2017

6.8K
Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
07:04

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

1.3K

Related Experiment Videos

Last Updated: Apr 11, 2026

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
06:12

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Published on: March 17, 2023

2.1K
Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum
09:23

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum

Published on: December 13, 2017

6.8K
Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
07:04

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

1.3K

Area of Science:

  • Biomedical Engineering
  • Immunology
  • Analytical Chemistry

Background:

  • Accurate blood group typing is critical for safe blood transfusions.
  • Current blood typing methods are subjective and require trained personnel.
  • Limited techniques exist for quantifying blood group antibody-antigen interactions.

Purpose of the Study:

  • To develop a fully regenerable, multi-functional platform for quantitative blood group typing.
  • To utilize surface plasmon resonance (SPR) for quantifying interactions between red blood cells (RBCs) and antibodies.

Main Methods:

  • Immobilization of anti-human IgG antibody onto an SPR sensor surface.
  • Incubation of RBCs with IgG antibodies (e.g., anti-D IgG) followed by binding to the sensor.
  • Quantitative detection of antibody-antigen interactions using SPR signal (response units, RU).

Main Results:

  • A clear distinction between D-antigen positive (>500 RU) and negative (<100 RU) RBCs was achieved.
  • The anti-human IgG surface demonstrated complete regenerability with negligible degradation after over 100 cycles.
  • The platform was validated using human-sourced whole blood samples.

Conclusions:

  • A novel, highly regenerable SPR-based platform enables quantitative blood group typing.
  • This approach offers a reliable and objective alternative to existing subjective blood typing methods.
  • The developed system demonstrates significant potential for clinical applications in blood transfusion diagnostics.