Related Experiment Video
Updated: Apr 11, 2026

A Freeze-Thawing Method to Prepare Chitosan-Polyvinyl alcohol Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
Published on: January 14, 2020
Crosslinking of alginic acid/chitosan matrices using polycarboxylic acids and their utilization for sodium diclofenac
H M Fahmy1, Moustafa M G Fouda1
1Textile Research Division, National Research Centre, Dokki, Cairo, Egypt.
Abstract:
Three different ratios of alginic acid/chitosan matrices of ratios 3/1, 1/1 and 1/2, respectively, were crosslinked in their dry state using citric acid (CA)/sodium hypophosphite (SHP) at different conditions controlling the crosslinking process such as citric acid concentration, citric acid/sodium hypophosphite molar ratio as well as time and temperature of reaction. Results indicate that such matrices were crosslinked efficiently on curing at 180°C for 9min in presence of CA/SHP ratio 1 and the citric acid concentration of 0.6 based on the weight of any matrices. The crosslinked matrices were characterized by investigating their swelling properties, FT-IR and thermalgravimetric analysis. Furthermore, such crosslinked matrices were tested as drug release for sodium diclofenac.
More Related Videos
12:22Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
Published on: October 26, 2016
07:24Author Spotlight: Advancing Therapeutics with Biocompatible Sodium Alginate Hydrogel Microspheres
Published on: June 7, 2024
Related Concept Videos
Modified-Release Drug Delivery Systems: Rate-Programmed I
Anionic Chain-Growth Polymerization: Overview
Oral Drug Delivery Systems: Delayed-Release Systems
Site-Targeted Drug Delivery Systems: Polymeric Carriers