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Coagulation parameters and platelet function analysis in patients with acromegaly.

A Colak1, H Yılmaz2, Y Temel1

  • 1Department of Biochemistry, Tepecik Research and Training Hospital, Izmir, Turkey.

Journal of Endocrinological Investigation
|June 7, 2015
PubMed
Summary

Acromegaly patients show increased clotting factors and enhanced platelet activity, suggesting a higher risk of cardiovascular and cerebrovascular events. This study investigated coagulation and platelet function in acromegaly.

Keywords:
AcromegalyCoagulationPlatelet function analysis

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Area of Science:

  • Endocrinology
  • Hematology
  • Cardiovascular Medicine

Background:

  • Acromegaly, a disorder of excessive growth hormone (GH) and insulin-like growth factor 1 (IGF-1) secretion, is linked to increased cardiovascular risks.
  • Limited data exist on coagulation and fibrinolysis in acromegaly, with platelet function uninvestigated.

Purpose of the Study:

  • To investigate protein C, protein S, fibrinogen, antithrombin 3 levels, and platelet function in acromegalic patients.
  • To assess the potential hypercoagulable state in acromegaly.

Main Methods:

  • Compared 39 active acromegaly patients with 35 healthy controls.
  • Measured plasma glucose, lipid profile, GH, IGF-1, protein C, protein S, antithrombin III, and platelet function (collagen/ADP and collagen/epinephrine closure times).

Main Results:

  • Acromegaly patients had higher GH, IGF-1, fibrinogen, and antithrombin III levels.
  • Protein C and protein S activities were significantly lower in acromegaly patients.
  • Platelet function was significantly enhanced in acromegaly patients, with negative correlations between IGF-1 and protein C/S, and positive correlation between IGF-1 and fibrinogen.

Conclusions:

  • Acromegaly is associated with an increased tendency towards coagulation and enhanced platelet activity.
  • This hypercoagulable state may contribute to the elevated risk of cardiovascular and cerebrovascular events in acromegaly patients.