Related Experiment Video
Updated: Apr 11, 2026

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
Published on: March 25, 2020
Impact of cholesterol on disease progression
Chun-Jung Lin1, Cheng-Kuo Lai, Min-Chuan Kao
1Department of Urology, University of Texas Southwestern Medical Center, Texas, Dallas, 75235, USA.
Abstract:
Cholesterol-rich microdomains (also called lipid rafts), where platforms for signaling are provided and thought to be associated with microbe-induced pathogenesis and lead to cancer progression. After treatment of cells with cholesterol disrupting or usurping agents, raft-associated proteins and lipids can be dissociated, and this renders the cell structure nonfunctional and therefore mitigates disease severity. This review focuses on the role of cholesterol in disease progression including cancer development and infectious diseases. Understanding the molecular mechanisms of cholesterol in these diseases may provide insight into the development of novel strategies for controlling these diseases in clinical scenarios.
More Related Videos
Related Concept Videos
Cholesterol: Significance and Regulation
Considering cholesterol and...
Atherosclerosis I: Introduction
Inflammation
Atherosclerosis III: Management
Coronary Artery Disease I: Introduction
Coronary Artery Disease II: Pathophysiology

