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AIM/CD5L: a key protein in the control of immune homeostasis and inflammatory disease

Lucía Sanjurjo1, Gemma Aran1, Nerea Roher1

  • 1*Innate Immunity Group, Health Sciences Research Institute Germans Trias i Pujol, Badalona, Spain; Evolutive Immunology Group, Institute of Biotechnology and Biomedicine, Universitat Autònoma de Barcelona, Barcelona, Spain; Nuclear Receptor Group, Department of Physiology and Immunology, School of Biology, University of Barcelona, Barcelona, Spain; and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain.

Journal of Leukocyte Biology
|June 7, 2015
PubMed

Insights

CD5L protein, regulated by LXRs, plays a key role in immune responses and lipid homeostasis. It acts as a pattern recognition receptor and shows potential as a diagnostic biomarker for diseases like TB and liver cirrhosis.

Area of Science:

  • Immunology
  • Molecular Biology
  • Biochemistry

Background:

  • CD5L is a soluble SRCR superfamily protein primarily expressed by macrophages in immune and inflamed tissues.
  • Its expression is transcriptionally regulated by Liver X Receptors (LXRs), crucial for lipid homeostasis.
  • CD5L has emerged as a significant player in immune responses, acting as a pattern recognition receptor (PRR).

Purpose of the Study:

  • To review current knowledge on CD5L.
  • To elucidate CD5L's roles in lipid homeostasis and immune response.
  • To explore CD5L's potential as a diagnostic biomarker for various diseases.

Main Methods:

  • Literature review of research on CD5L.
  • Analysis of CD5L's molecular functions.
  • Evaluation of CD5L's involvement in disease pathogenesis.

Main Results:

  • CD5L functions as a PRR for bacterial and fungal components.
  • CD5L is involved in controlling inflammatory responses.
  • CD5L has implications in atherosclerosis, cancer, and infectious diseases like TB.

Conclusions:

  • CD5L is a critical link between lipid metabolism and immune function.
  • CD5L demonstrates potential as a diagnostic biomarker for conditions including TB and liver cirrhosis.
  • Further research into CD5L could yield new therapeutic strategies.
Keywords:
SRCR domainSpαcancermacrophagemetabolic disease

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