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Related Experiment Video

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The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
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Thrombus deflector stent for stroke prevention: A simulation study.

Hyo Won Choi1, Jose A Navia2, Ghassan S Kassab1

  • 1The California Medical Innovations Institute, 11107 Roselle Street, San Diego, CA 92121, United States.

Journal of Biomechanics
|June 8, 2015
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Summary

A novel device design can deflect blood clots away from the carotid artery, reducing stroke risk in atrial fibrillation (AF) patients. Optimized strut configurations maximize clot deflection efficacy.

Keywords:
Aortic flowAtrial fibrillationComputational fluid dynamicsEmbolusMultiphase flowVascular device

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Area of Science:

  • Cardiovascular Engineering
  • Biomedical Fluid Dynamics
  • Stroke Prevention Technologies

Background:

  • Atrial fibrillation (AF) increases ischemic stroke risk due to altered hemodynamics promoting clot formation and embolism.
  • Blood clots traveling through carotid arteries are a primary cause of stroke in AF patients.
  • Current stroke prevention methods have limitations, necessitating innovative device development.

Purpose of the Study:

  • To computationally simulate and assess a novel strut-structured device designed to deflect blood clots.
  • To identify key design determinants influencing the device's clot deflection efficacy under AF conditions.
  • To evaluate the potential of this device as an effective stroke-prevention strategy.

Main Methods:

  • Computational fluid dynamics (CFD) simulations were employed to model blood flow and clot trajectories.
  • Various clot dimensions and device strut configurations were analyzed under simulated AF flow.
  • Deflection efficacy was quantitatively assessed for different strut designs, including thickness, distance, and surface convexity.

Main Results:

  • The strut-structured device effectively deflected clots away from the left common carotid artery (LCCA) inlet.
  • Deflection efficacy was significantly influenced by clot properties and specific strut designs.
  • A configuration with 0.75 mm struts, 0.75 mm spacing, and 50% surface convexity yielded maximum deflection (36% higher than a flat filter).
  • The device demonstrated minimal impact on overall flow resistance.

Conclusions:

  • A deflector stent with optimized strut geometry shows promise as an effective stroke-prevention device for AF patients.
  • The findings support further pre-clinical and patient-specific design studies to maximize efficacy and ensure safety.
  • This computational approach provides a foundation for developing advanced embolic protection devices.