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Acute effects of mechanical dyssynchrony on left ventricular function and coronary perfusion
Jenny S Choy1, Lei Fan2, Yousif Awakeem1
1California Medical Innovations Institute, Inc., San Diego, CA, United States.
Frontiers in Bioengineering and Biotechnology
|September 29, 2025
Summary
Mechanical dyssynchrony in heart failure impairs left ventricular (LV) function and coronary perfusion. This study links reduced LV contractility and work to decreased coronary flow, impacting cardiac resynchronization therapy outcomes.
Area of Science:
- Cardiology
- Biomedical Engineering
- Physiology
Background:
- Heart failure often involves mechanical dyssynchrony, negatively impacting ventricular function and coronary perfusion.
- The precise mechanisms underlying these effects are not fully understood due to confounding factors.
Purpose of the Study:
- To investigate the acute effects of mechanical dyssynchrony on global and regional left ventricular (LV) function.
- To analyze the impact on coronary perfusion and their interactions.
- To utilize both experimental and computational approaches.
Main Methods:
- Mechanical dyssynchrony was induced in swine via right ventricular apical pacing at varying rates (100 and 140 bpm).
- An inverse finite element computational model, specific to the animal's LV geometry, was developed.
- The model correlated LV function with regional coronary perfusion.
Main Results:
- Mechanical dyssynchrony significantly reduced LV pressure, volume, stroke volume, ejection fraction, and regional strain.
- Coronary flow decreased substantially in the LAD (70%) and LCX (67%).
- The computational model predicted decreased global and regional LV contractility and myocardial work.
Conclusions:
- Reduced LV contractility and myocardial work in dyssynchrony correlate with decreased coronary flow.
- This interplay between LV function and coronary flow may influence patient response to cardiac resynchronization therapy.
Keywords:
coronary blood flowleft ventricular functionleft ventricular hemodynamicsmechanical dyssynchronyright ventricular pacingMore Related Videos
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