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Updated: Apr 11, 2026

Targeted Antibody Blocking by a Dual-Functional Conjugate of Antigenic Peptide and Fc-III Mimetics DCAF
Published on: September 17, 2019
Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC)
João P M Nunes1, Maurício Morais, Vessela Vassileva
1Department of Chemistry, University College London, London, WC1H 0AJ, UK. j.r.baker@ucl.ac.uk v.chudasama@ucl.ac.uk.
Abstract:
Herein we report the use of next generation maleimides (NGMs) for the construction of a potent antibody-drug conjugate (ADC) via functional disulfide bridging. The linker has excellent stability in blood serum and the ADC, armed with monomethyl auristatin E (MMAE), shows excellent potency and cancer cell selectivity in vitro.
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