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Updated: Apr 11, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
A cationic gadolinium contrast agent for magnetic resonance imaging of cartilage
Jonathan D Freedman1,2, Hrvoje Lusic3, Martin Wiewiorski2
1Department of Pharmacology at Boston University and Boston University School of Medicine, Boston, MA.
Abstract:
A new cationic gadolinium contrast agent is reported for delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC). The agent partitions into the glycosaminoglycan rich matrix of articular cartilage, based on Donnan equilibrium theory, and its use enables imaging of the human cadaveric metacarpal phalangeal joint.
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