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Regioselective Cross-Couplings of Coumarins and Flavones with Ethers via C(sp(3))-H Functionalization
Ben Niu1, Wannian Zhao1, Yingcai Ding1
1†Pharmacy School, Jiangsu University, Xuefu Road 301, Zhenjiang City, Jiangsu 212013, China.
Abstract:
Coumarin and flavone derivatives are highly valuable molecules in drug discovery. Here, two new regioselective cross-dehydrogenation couplings of coumarins and flavones with different ethers via C(sp(3))-H functionalization processes were developed, generating new ether-substituted derivatives not previously reported. These reactions proceeded well via radical mechanisms and provided the corresponding products in good yields.
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