Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thromboresistant polymers: a new approach.

J E Wilson1, C E Jones

  • 1Department of Physiology, Texas College of Osteopathic Medicine, Fort Worth 76107.

Biomaterials, Artificial Cells, and Artificial Organs
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management of asthma in pregnancy.

Clinical medicine (London, England)·2024
Same author

Congenital Cytomegalovirus Infection: Update on Screening, Diagnosis and Treatment: Scientific Impact Paper No. 56.

BJOG : an international journal of obstetrics and gynaecology·2024
Same author

Improving paediatric antimicrobial stewardship in hospital-based settings: why, where and how?

JAC-antimicrobial resistance·2021
Same author

Repair of oesophageal atresia by consultants and supervised trainees results in similar outcomes.

Annals of the Royal College of Surgeons of England·2020
Same author

The effectiveness of influenza vaccination in pregnancy in relation to child health outcomes: Systematic review and meta-analysis.

Vaccine·2020
Same author

Quality of research: Improper evaluation of the quality of trials of retention rates.

British dental journal·2019
Same journal

The enhanced attachment and growth of endothelial cells on anhydrous ammonia gaseous plasma modified surfaces of polystyrene and poly(tetrafluoroethylene).

Biomaterials, artificial cells, and artificial organs·1990
Same journal

New method to quantitate platelets adhered on biomaterials using monoclonal antibodies to human platelet membrane glycoprotein SZ-21.

Biomaterials, artificial cells, and artificial organs·1990
Same journal

The influence of vaccines and hyper immune serums on protein/platelet interaction towards an artificial surface.

Biomaterials, artificial cells, and artificial organs·1990
Same journal

Ectopic bone induction by partially purified bone extract alone or attached to biomaterials.

Biomaterials, artificial cells, and artificial organs·1990
Same journal

Characteristics of immobilized aminoacylase from Aspergillus oryzae on macroporous copolymers.

Biomaterials, artificial cells, and artificial organs·1990
Same journal

Use of cell culture to predict toxicity of solid materials in blood contact.

Biomaterials, artificial cells, and artificial organs·1990
See all related articles

Selected antithrombotic agents improve polysilicone tube blood compatibility. Covalently bonding these agents enhances thromboresistance, potentially by managing calcium ions crucial for blood coagulation.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Hemostasis Research

Background:

  • Polysilicone materials are widely used in medical devices.
  • Improving the thromboresistance of biomaterials is critical for preventing blood clots.
  • Antithrombotic agents can inhibit blood coagulation.

Purpose of the Study:

  • To covalently bind antithrombotic agents to polysilicone tubes.
  • To evaluate the effect of bound antithrombotic agents on thromboresistance.
  • To investigate the potential mechanism of action for improved blood compatibility.

Main Methods:

  • Radiation grafting of epoxypropyl acrylate monomer onto polysilicone tubes.
  • Covalent bonding of antithrombotic agents via reaction with epoxy groups.

Related Experiment Videos

  • Pilot studies to assess thromboresistance of modified tubes.

    • Main Results:

    • Successful covalent attachment of antithrombotic agents to polysilicone tubes.
    • Demonstrated improved thromboresistance of the modified polysilicone tubes.
    • Hypothesized mechanism involving calcium ion chelation/complexation.

    Conclusions:

    • Covalent binding of antithrombotic agents is an effective strategy to enhance polysilicone thromboresistance.
    • The improved blood compatibility may be linked to the modulation of calcium-dependent coagulation pathways.
    • This approach holds promise for developing more hemocompatible medical devices.