Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.9K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.9K
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

2.3K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
2.3K
Stem Cell Culture01:17

Stem Cell Culture

6.6K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
6.6K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

3.4K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.4K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.3K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Theoretical and Centrifuge Modeling Experimental Monitoring Study on the Seismic Behavior of an Inclined Crack in a Slope.

Sensors (Basel, Switzerland)·2026
Same author

Target degradation of CASPASE-1 for alleviation of inflammation in sepsis <i>via</i> optogenetically engineered extracellular vesicles.

Acta pharmaceutica Sinica. B·2026
Same author

Targeting Soluble PD-1 Alleviates Peritoneal Fibrosis by Modulating PD-L1 Recycling and Mesothelial-Mesenchymal Transition.

Translational research : the journal of laboratory and clinical medicine·2026
Same author

Bioengineered JMJD3-PROTAC targeted epigenetic immunotherapy strategy for diabetic periodontitis.

Journal of advanced research·2026
Same author

Bio-recruiting hydrogel targeting mitochondrial homeostasis under neutrophil extracellular traps for diabetic wound repair.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Soluble PD-1 drives renal fibrosis in CKD by disrupting immune homeostasis: Therapeutic mitigation via a targeted sPD-1 sequestration strategy.

Life sciences·2026

Related Experiment Video

Updated: Apr 11, 2026

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
08:32

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

Published on: March 22, 2024

2.0K

Harnessing endogenous stem/progenitor cells for tendon regeneration.

Chang H Lee, Francis Y Lee, Solaiman Tarafder

    The Journal of Clinical Investigation
    |June 9, 2015
    PubMed
    Summary

    This study shows that stimulating native tendon stem cells (CD146+) with connective tissue growth factor (CTGF) promotes tendon regeneration without cell transplantation. This approach restores tendon structure and function, offering a new strategy for tissue repair.

    More Related Videos

    Author Spotlight: Advancements in Cell and Tissue Engineering for Tendon Repair
    04:48

    Author Spotlight: Advancements in Cell and Tissue Engineering for Tendon Repair

    Published on: March 1, 2024

    2.5K
    Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats
    09:31

    Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats

    Published on: March 30, 2018

    11.8K

    Related Experiment Videos

    Last Updated: Apr 11, 2026

    Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
    08:32

    Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms

    Published on: March 22, 2024

    2.0K
    Author Spotlight: Advancements in Cell and Tissue Engineering for Tendon Repair
    04:48

    Author Spotlight: Advancements in Cell and Tissue Engineering for Tendon Repair

    Published on: March 1, 2024

    2.5K
    Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats
    09:31

    Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats

    Published on: March 30, 2018

    11.8K

    Area of Science:

    • Regenerative Medicine
    • Stem Cell Biology
    • Biomaterials Science

    Background:

    • Current tissue regeneration methods rely on ex vivo cell manipulation, facing challenges with cell transplantation.
    • Endogenous stem/progenitor cells offer a promising alternative, potentially avoiding transplantation hurdles.

    Purpose of the Study:

    • To investigate the use of endogenous tendon stem/progenitor cells for tendon regeneration in a rat model.
    • To explore the role of connective tissue growth factor (CTGF) in activating and directing these cells.

    Main Methods:

    • Identification and characterization of CD146+ tendon stem/progenitor cells.
    • Enrichment of these cells using CTGF delivery during specific phases of tendon healing.
    • Assessment of tendon regeneration, collagen alignment, cellularity, and functional restoration.
    • Evaluation of the FAK/ERK1/2 signaling pathway using siRNA knockdown.

    Main Results:

    • A rare population of CD146+ tendon cells with stem/progenitor characteristics was identified.
    • CTGF delivery successfully enriched CD146+ cells and promoted their tenogenic differentiation.
    • Regenerated tendons exhibited dense collagen, normal cellularity, and restored function.
    • The FAK/ERK1/2 pathway was found to regulate CTGF-induced stem/progenitor cell activity.

    Conclusions:

    • Endogenous CD146+ stem/progenitor cells can be stimulated by CTGF for effective tendon regeneration.
    • This strategy bypasses the need for cell transplantation, offering a novel approach to tendon repair.
    • The findings suggest potential applications for endogenous stem cell activation in other tissue regeneration contexts.