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Association of inflammatory markers and poor outcome in diabetic patients presenting with ST segment elevation

Yulia Belenkova1, Viktoria Karetnikova1, Aleksey Diachenko2

  • 1Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian Federation ; State Budgetary Educational Institution of Higher Professional Education Kemerovo State Medical Academy of the Russian Ministry of Health, Kemerovo, Russian Federation.

Journal of Inflammation Research
|June 10, 2015
PubMed

Insights

Carbohydrate metabolism disorders worsen ischemic heart disease outcomes. Inflammation, particularly in diabetic patients with ST-elevation myocardial infarction (STEMI), predicts poor prognosis despite revascularization.

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Inflammation Research

Background:

  • Carbohydrate metabolism disorders (CMD) are linked to ischemic heart disease (IHD) progression.
  • Inflammation acts as a key pathogenetic factor connecting CMD and IHD.

Purpose of the Study:

  • To investigate the impact of CMD on 1-year outcomes in ST-segment elevation myocardial infarction (STEMI) patients.
  • To analyze the role of inflammation markers in STEMI patients with and without CMD.

Main Methods:

  • Registry study of 601 STEMI patients admitted within 24 hours.
  • Measurement of inflammation markers (IL-6, sCD40L, IL-12) at days 10-14 post-MI.
  • 1-year follow-up to assess outcomes, including the impact of percutaneous coronary intervention.

Main Results:

  • Percutaneous coronary intervention improved 1-year prognosis for STEMI patients, irrespective of CMD status.
  • Higher IL-6 and sCD40L levels were observed in MI patients with diabetes mellitus and impaired glucose tolerance.
  • Impaired glucose tolerance correlated with higher IL-12 levels; high Killip classification indicated poor outcomes in diabetic MI patients.

Conclusions:

  • Persistent inflammation in STEMI patients with CMD may lead to vascular complications within 1 year post-MI.
  • Comorbid diabetes or impaired glucose tolerance exacerbates the inflammatory response and adverse outcomes.
Abstract

Keywords:
carbohydrate metabolism disordersinflammation percutaneous coronary intervention

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