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Updated: Apr 11, 2026

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus
Published on: May 7, 2012
A 47-year-old stem cell transplant recipient with fever, cough and chest pain
Abstract:
Infections and malignancies are among the most serious complications that follow organ or stem cell transplantation. They may have a mild course, and nonspecific and overlapping manifestations. The present article describes a case of symptomatic nodular pulmonary disease that complicated hematopoietic stem cell transplantation. It was diagnosed to be post-transplant lymphoproliferative disorder, a potential sequela of immunosuppression and a very difficult entity to treat in profoundly immunosuppressed patients.
Insights
Post-transplant lymphoproliferative disorder (PTLD) can cause serious pulmonary complications after stem cell transplantation. This case highlights PTLD as a challenging diagnosis in immunocompromised patients.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Organ and stem cell transplantation carry risks of serious complications, including infections and malignancies.
- These complications can present with nonspecific and overlapping symptoms, complicating diagnosis.
- Post-transplant lymphoproliferative disorder (PTLD) is a significant concern following transplantation.
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