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High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

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Published on: March 24, 2015

Interferons and systemic sclerosis: correlation between interferon gamma and interferon-lambda 1 (IL-29).

Andréa Tavares Dantas^1,2, Sayonara Maria Calado Gonçalves², Michelly Cristiny Pereira²

¹a Hospital das Clínicas da Universidade Federal de Pernambuco (UFPE) , Brazil .

|June 10, 2015

Summary

Systemic sclerosis (SSc) patients show elevated levels of Interferon (IFN)-λ1 and IFN-γ. These cytokines correlate with each other and with specific SSc clinical manifestations, suggesting a role in disease pathogenesis.

Keywords:

Cytokine interferon-gamma interferon-lambda1 interleukin-29 scleroderma

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Published on: July 16, 2019

Area of Science:

Immunology
Rheumatology
Cytokine Biology

Background:

Interferon (IFN)-λ1, a type III interferon, exhibits antiviral, anti-proliferative, and antitumor activities.
Emerging evidence suggests immune-regulatory functions for IFN-λ1, but its role in autoimmune disease pathogenesis remains unclear.
Systemic sclerosis (SSc) is a complex autoimmune condition with incompletely understood pathogenic mechanisms.

Purpose of the Study:

To investigate serum levels of Interferon (IFN)-λ1 in patients with systemic sclerosis (SSc).
To assess the association between IFN-λ1 levels and IFN-γ serum levels in SSc.
To explore the correlation of these cytokine levels with clinical manifestations in SSc patients.

Main Methods:

Serum samples were collected from 52 SSc patients and 53 healthy controls.
Enzyme-linked immunosorbent assay (ELISA) was employed to quantify serum levels of IFN-λ1 and IFN-γ.
Statistical analyses were performed to determine associations between cytokine levels and clinical parameters.

Main Results:

Significantly higher serum levels of both IFN-λ1 and IFN-γ were observed in SSc patients compared to healthy individuals (p < 0.0001).
A positive correlation was found between serum levels of IFN-λ1 and IFN-γ in SSc patients (p = 0.0103).
IFN-γ levels were significantly associated with muscle involvement (myositis) in SSc patients (p = 0.0483).

Conclusions:

This study provides the first evidence of elevated serum IFN-λ1 levels in patients with systemic sclerosis.
The findings demonstrate a correlation between IFN-λ1 and IFN-γ levels and link IFN-γ to myositis in SSc.
Further in vitro and in vivo investigations are warranted to elucidate the specific role of IFN-λ1 in SSc pathogenesis.