Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.

Pulmonary Tuberculosis III

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Acute exacerbation in fibrotic interstitial lung disease: An International Working Group Report.

American journal of respiratory and critical care medicine·2026

Same author

Pulmonary fibrosis after COVID-19 is characterized by airway abnormalities and elevated club cell secretory protein-16.

JCI insight·2026

Same author

Geographical, institutional and workplace variability in genetic evaluation, screening practices, multidisciplinary care, and lung transplantation management for familial interstitial lung disease.

BMC pulmonary medicine·2026

Same author

Prevalence, detection, and trajectory of combined pulmonary fibrosis and emphysema.

Chest·2026

Same author

The 2025 ATS/ERS update of the international multidisciplinary classification of the interstitial pneumonias: implications for the pathologist.

Histopathology·2026

Same author

Clinical and Radiologic Characteristics of Familial Pulmonary Fibrosis.

Annals of the American Thoracic Society·2026

Search research articles

Related Experiment Video

Updated: Apr 11, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Unclassifiable interstitial lung disease: A review.

Kate Skolnik¹, Christopher J Ryerson²

¹Department of Medicine, University of Calgary, Calgary, Alberta, Canada.

Respirology (Carlton, Vic.)

|June 11, 2015

Summary

Accurate interstitial lung disease (ILD) classification needs expert collaboration, yet some cases remain unclassifiable. Further research is vital for defining and managing these challenging ILD diagnoses.

Keywords:

diffuse lung disease idiopathic interstitial pneumonia idiopathic pulmonary fibrosis interstitial lung disease unclassifiable

More Related Videos

Point-of-Care Lung Ultrasound in Adults: Image Acquisition

Point-of-Care Lung Ultrasound in Adults: Image Acquisition

Published on: March 3, 2023

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

Related Experiment Videos

Last Updated: Apr 11, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Point-of-Care Lung Ultrasound in Adults: Image Acquisition

Point-of-Care Lung Ultrasound in Adults: Image Acquisition

Published on: March 3, 2023

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

Area of Science:

Pulmonology
Radiology
Pathology

Background:

Accurate interstitial lung disease (ILD) diagnosis relies on a multidisciplinary team including respirologists, radiologists, and pathologists.
A significant percentage of patients (up to 15%) are diagnosed with unclassifiable ILD, hindering specific treatment strategies.

Purpose of the Study:

To define unclassifiable ILD and its characteristics.
To identify challenges in ILD classification.
To propose management strategies for unclassifiable ILD.

Main Methods:

This review synthesizes current literature on unclassifiable ILD.
It examines existing definitions, diagnostic barriers, and management approaches.
Recent studies characterizing these patients are discussed.

Main Results:

Inconsistencies exist in the definition and terminology of unclassifiable ILD due to limited research.
The characteristics of patients with unclassifiable ILD are being increasingly described.
Barriers to classification include the complexity of ILD and the need for specialized expertise.

Conclusions:

Unclassifiable ILD presents a diagnostic challenge despite multidisciplinary evaluation.
Further research is essential to standardize definitions and develop effective management protocols.
Improved understanding and research are needed for optimal patient care in unclassifiable ILD.