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MPV and other inflammatory markers in diagnosing acute appendicitis

Seyran Bozkurt1, Ataman Köse1, Semra Erdogan2

  • 1Emergency Medicine Department, Mersin University Medical Faculty, Mersin, Turkey.

JPMA. the Journal of the Pakistan Medical Association
|June 11, 2015
PubMed
Abstract

Insights

Elevated white blood cell and neutrophil counts show promise for diagnosing acute appendicitis. However, mean platelet volume and C-reactive protein are not effective diagnostic markers for this condition.

Area of Science:

  • Medical Diagnostics
  • Inflammatory Markers
  • Gastrointestinal Surgery

Background:

  • Acute appendicitis is a common surgical emergency.
  • Accurate and timely diagnosis is crucial to prevent complications.
  • Inflammatory markers are often used to aid diagnosis, but their utility varies.

Purpose of the Study:

  • To evaluate mean platelet volume (MPV) as a potential inflammatory marker for acute appendicitis.
  • To compare the diagnostic value of MPV with white blood cell (WBC) count, neutrophil count, and C-reactive protein (CRP).

Main Methods:

  • Retrospective analysis of 275 patients undergoing appendectomy.
  • Categorization into uncomplicated appendicitis, complicated appendicitis, and non-appendicitis groups based on pathology.
  • Comparison of preoperative WBC count, neutrophil count, CRP, and MPV levels across groups.

Main Results:

  • WBC and neutrophil counts were significantly higher in appendicitis groups compared to non-appendicitis cases (p<0.001).
  • MPV levels did not show a statistically significant difference between groups (p=0.478).
  • Neutrophil count demonstrated higher sensitivity and specificity than MPV and CRP for diagnosing appendicitis.

Conclusions:

  • Elevated white blood cell and neutrophil counts are valuable diagnostic indicators for acute appendicitis.
  • Mean platelet volume and C-reactive protein are not reliable diagnostic markers for acute appendicitis.
Keywords:
Acute appendicitis, Mean platelet volume, C-reactive protein, Leucocyte count.

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