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Related Concept Videos

Seizures: Classification01:13

Seizures: Classification

2.3K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
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Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

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Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
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Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

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Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
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Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

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γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
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Related Experiment Video

Updated: Apr 11, 2026

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
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Complex Partial Epilepsy Associated with Temporal Lobe Developmental Venous Anomaly.

Amna Sohail1, Zhengming Xiong2, Mushtaq H Qureshi1

  • 1Zeenat Qureshi Stroke Institute, Saint Cloud, Minnesota, MN, USA.

Journal of Vascular and Interventional Neurology
|June 11, 2015
PubMed
Summary

Developmental venous anomalies (DVA) can cause neurological issues. This case shows a DVA linked to complex partial seizures, diagnosed via MRI and angiography.

Keywords:
Complex partial epilepsydevelopmental venous anomaly

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Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE
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Area of Science:

  • Neurology
  • Radiology
  • Vascular Malformations

Background:

  • Developmental venous anomalies (DVA) are often incidental findings.
  • However, some patients with DVA experience neurological symptoms.

Purpose of the Study:

  • To report a case of early-onset complex partial epilepsy associated with DVA.
  • To discuss the natural history, neuroimaging, clinical characteristics, and management of such cases.

Main Methods:

  • Case presentation of a 21-year-old male with complex partial epilepsy since age 4.
  • Electroencephalogram (EEG) showed left frontotemporal spike and wave discharges.
  • Magnetic resonance imaging (MRI) revealed a linear flow void suggestive of DVA.
  • Angiography confirmed DVA connected to the left transverse venous sinus and an anastomotic vein.

Main Results:

  • The patient presented with complex partial epilepsy with secondary generalization.
  • EEG and MRI findings were consistent with a left frontotemporal DVA.
  • Angiography provided detailed vascular anatomy.

Conclusions:

  • Temporal lobe DVA can be associated with complex partial seizures.
  • MRI and angiographic findings are crucial for diagnosing DVA and related epilepsy.