Evaluating the Y chromosomal STR dating in deep-rooting pedigrees.

Area of Science:

• Population Genetics
• Anthropology
• Genetics

Background:

• Y chromosomal short tandem repeats (STRs) are utilized for estimating divergence times of lineages and identifying eminent individuals.
• Controversy exists regarding the optimal mutation rates and estimation methodologies for Y chromosome dating, leading to significant deviations in results.

Purpose of the Study:

• To directly evaluate Y chromosomal STR mutation rates and dating methods.
• To identify the most reliable approach for historical lineage dating using genetic markers.

Main Methods:

• Utilized two deep-rooting pedigrees with comprehensive records and validated dates.
• Applied the BATWING method to analyze Y chromosomal STR data.
• Evaluated various mutation rates, including OMRB and lmMR.

Main Results:

• Direct evaluation of Y chromosomal STR mutation rates and dating methods was performed.
• The Y chromosomal genealogical mutation rates (OMRB and lmMR) within the BATWING method demonstrated the best fit for historical lineage dating.
• This approach minimizes the multi-fold deviations observed with other methods.

Conclusions:

• The study validates an efficient and reliable method for genealogical research.
• The findings offer a robust tool for historical anthropology and population genetics studies.
• Accurate Y chromosome dating is crucial for understanding human history and lineage evolution.