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Effect of Vitamin E and Metformin on Fatty Liver Disease in Obese Children- Randomized Clinical Trial

Kobra Shiasi Arani1, Abbas Taghavi Ardakani2, Razieh Moazami Goudarzi2

  • 11. Research Center for Biochemistry and Nutrition in Metabolic Disorders, Kashan University of Medical Sciences , Kashan, Iran.

Iranian Journal of Public Health
|June 11, 2015
PubMed

Insights

Vitamin E and metformin show effectiveness in treating fatty liver disease in obese children. Vitamin E, particularly at 400 U daily, demonstrated better outcomes over a four-month period compared to metformin.

Area of Science:

  • Pediatric Hepatology
  • Nutritional Science
  • Clinical Pharmacology

Background:

  • Non-alcoholic fatty liver disease (NAFLD) is a growing concern in obese children.
  • Evaluating therapeutic interventions for pediatric NAFLD is crucial.

Purpose of the Study:

  • To assess the efficacy of vitamin E and metformin in treating NAFLD in obese children.
  • To compare the effectiveness of different dosages and treatment durations.

Main Methods:

  • An interventional study involving 119 obese children diagnosed with NAFLD via sonography.
  • Patients were randomized into four groups receiving metformin (1g or 1.5g daily) or vitamin E (400 U or 800 U daily).
  • Liver sonography was conducted at two-month intervals over four months.

Main Results:

  • Overall, liver sonography normalized in 55.46% of patients.
  • After two months, vitamin E 800 U daily showed the highest response rate (48.1%).
  • After four months, vitamin E 400 U daily exhibited a greater response (45.8%) compared to metformin.

Conclusions:

  • Vitamin E appears more influential than metformin in achieving NAFLD remission in children.
  • Both vitamin E and metformin are effective treatments for pediatric fatty liver disease.
  • Vitamin E at 400 U daily demonstrated superior efficacy in four-month treatment protocols.
Abstract

Keywords:
ChildrenFatty liver diseaseMetforminObesityVitamin E

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