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Updated: Apr 10, 2026
07:29
Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure
Published on: August 14, 2017
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Defining Post Hepatectomy Liver Insufficiency: Where do We stand?
Kelly Lafaro1,2, Stefan Buettner1, Hadia Maqsood1
1Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Summary
Post-hepatectomy liver failure (PHLF) is a significant risk after liver resection. This review details PHLF
Area of Science:
- Hepatobiliary Surgery
- Gastroenterology
- Clinical Medicine
Background:
- Post-hepatectomy liver failure (PHLF) is a critical complication following liver resection.
- It significantly contributes to patient morbidity and mortality.
- Understanding PHLF is crucial for improving surgical outcomes.
Purpose of the Study:
- To provide a comprehensive review of current literature on PHLF.
- To cover definition, risk factors, assessment, grading, prevention, and management.
- To consolidate knowledge for clinical application.
Main Methods:
- Systematic literature search conducted across major databases (PubMed, Medline, Cochrane).
- Keywords included "liver failure", "posthepatectomy", and "hepatic resection".
- Focused on recent publications for up-to-date information.
Main Results:
- Liver resection, while curative for tumors, can lead to hepatocyte loss and impaired regeneration.
- Patient-specific factors, liver parenchyma status, and surgical extent influence regeneration.
- These factors collectively increase the risk of developing PHLF.
Conclusions:
- PHLF presents a treatment challenge with high associated mortality.
- Accurate identification of high-risk patients is paramount.
- Developing effective preventative and management strategies is an ongoing priority.
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