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The Rabbit Model of Accelerated Atherosclerosis: A Methodological Perspective of the Iliac Artery Balloon Injury

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Testin on Atherosclerosis in Rabbits.

Yue Zhang, Meng Yuan, Hong-Min Li

¹Department of Cardiology, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease (Key Lab-TIC), Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, China.

Chinese Medical Journal

|June 12, 2015

Summary

Down-regulation of the TES (tumor suppressor gene) is linked to atherosclerosis development. Reduced TES expression in rabbits fed a high-fat diet indicates its potential role in this cardiovascular disease.

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Last Updated: Apr 10, 2026

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Published on: June 12, 2019

Area of Science:

Cardiovascular Research
Molecular Biology
Pathogenesis of Atherosclerosis

Background:

TES, a novel tumor suppressor gene, shows reduced expression in coronary artery disease patients.
This study investigates TES expression during atherosclerosis development.

Purpose of the Study:

To examine the role of TES/Testin expression in diet-induced atherosclerosis in a rabbit model.
To correlate TES/Testin levels with atherosclerotic plaque formation and lipid profiles.

Main Methods:

Rabbits were fed normal or high-fat diets for 12 weeks.
Atherosclerosis was assessed via histology; TES/Testin expression was measured using immunohistochemistry, immunofluorescence, real-time PCR, and Western blot.

Main Results:

High-fat diet induced higher serum lipids and atherosclerotic plaques.
TES mRNA and protein levels were significantly reduced in rabbits on a high-fat diet.
Testin expression was localized to the endothelium and subendothelium.

Conclusions:

Reduced TES/Testin expression is associated with atherosclerosis development.
TES/Testin may play a significant role in the pathogenesis of atherosclerosis.