Related Experiment Video
Updated: Apr 10, 2026
09:37
Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
Published on: August 1, 2018
15.6K
Platelet function parameters in management of hepatic hydatid disease: a case-controlled study
Bulent Dinc1, Serdar Dusen2, Nurettin Ay3
1Department of Surgery, Ataturk State Hospital Antalya 07040, Turkey.
Summary
Platelet function, assessed by MPV and PDW, differs significantly after hepatic hydatid disease surgery. These markers are useful for initial follow-up but less so for long-term monitoring of hepatic hydatid disease patients.
Area of Science:
- Hepatology
- Hematology
- Parasitology
Background:
- Hepatic hydatid disease (HD) is a parasitic infection requiring surgical intervention.
- Post-surgical monitoring of platelet function in HD patients is crucial for understanding recovery and potential complications.
Purpose of the Study:
- To evaluate platelet function in patients who have undergone surgical treatment for hepatic hydatid disease.
- To compare platelet parameters between preoperative, postoperative, and control groups.
Main Methods:
- A retrospective case-controlled study involving 53 hepatic HD patients and 55 healthy controls.
- Analysis of haematocrit (HTC), platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and eosinophil percentage (EOS).
- Comparison of laboratory records from preoperative and postoperative periods (day 1 and day 30, respectively).
Main Results:
- No significant differences were found in HTC, PLT, or EOS among the groups.
- Mean platelet volume (MPV) and platelet distribution width (PDW) showed significant differences between preoperative patients and both postoperative patients and controls.
- Long-term follow-up of nine patients with previous HD surgery revealed no significant MPV or PDW changes between preoperative and postoperative periods.
Conclusions:
- Mean platelet volume (MPV) and platelet distribution width (PDW) can serve as indicators of platelet function changes in the initial follow-up period after hepatic HD surgery.
- The utility of MPV and PDW for long-term monitoring of platelet function in hepatic HD patients is limited.
Related Concept Videos
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
261
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
261
01:26Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
345
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
345
01:18Structure and Function of Platelets
5.8K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
5.8K
01:14Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug
321
In pharmacotherapy, monitoring drug concentrations is paramount, especially for drugs whose therapeutic effects hinge on both the active compound and its metabolite. Hepatic impairment profoundly influences drug potency by altering liver function. If the drug is more potent than its metabolite, impaired liver function amplifies drug activity due to elevated drug concentration levels. Conversely, if the metabolite holds greater potency, diminished liver function diminishes drug activity by...
321
01:22Formation of the Platelet Plug
10.9K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
10.9K
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
2.5K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.5K