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Related Concept Videos

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Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: Apr 10, 2026

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[Recent progress and prospect in oligonucleotide therapeutics].

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    Oligonucleotide therapeutics, including antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs), show great promise for treating genetic diseases and cancers. Advances in chemical modification and delivery enhance their efficacy and clinical potential.

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    Area of Science:

    • Molecular Biology
    • Drug Delivery Systems
    • Biotechnology

    Context:

    • Oligonucleotide therapeutics, such as antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs), have advanced significantly.
    • Chemical modifications and nonviral delivery systems enhance their properties and efficacy.
    • Recent clinical trials show promise for cancers and genetic diseases.

    Purpose:

    • To review recent advances in the basic properties and clinical applications of ASO and siRNA.
    • To provide a future perspective on the development of oligonucleotide therapeutics.

    Summary:

    • ASOs function via mechanisms like mRNA degradation (RNase H) or alternative splicing modulation.
    • siRNA and ASO therapeutics demonstrate high clinical potency, as evidenced by successful trials.
    • This review covers fundamental aspects and clinical uses of ASO and siRNA.

    Impact:

    • Highlights the clinical potency of oligonucleotide therapeutics.
    • Indicates a promising future for ASO and siRNA in treating various diseases.
    • Provides insights into the ongoing development and application of nucleic acid-based therapies.