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Published on: January 14, 2020
An innovative method for preparation of acid-free-water-soluble low-molecular-weight chitosan (AFWSLMWC)
Wu Yue1, Pingjia Yao2, Yuanan Wei3
1College of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, People's Republic of China; Guangxi Key Lab for Subtropical Bio-Resource Conservation and Utilization, Guangxi University, Nanning 530004, People's Republic of China.
Abstract:
The ozone generated from compressed oxygen by a laboratory-scale corona discharge generator was used for the preparation of acid-free-water-soluble low-molecular-weight chitosan (AFWSLMWC). Factors affecting the percent yield of AFWSLMWC were studied in batch experiments. AFWSLMWC with a molecular weight of 4.3-13.1kDa was obtained. IR spectra demonstrated that the chemical structures of AFWSLMWC were not modified during the depolymerisation process. There was no significant change of the total degree of deacetylation (DD) of AFWSLMWC, compared with the initial chitosan. The method is promisingly suitable for scale-up manufacture of acid-free-water-soluble low-molecular-weight chitosan.
