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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots
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Cell encapsulation: technical and clinical advances.

Gorka Orive1, Edorta Santos1, Denis Poncelet2

  • 1Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, Vitoria, Spain; Networking Biomedical Research Center on Bioengineering, Biomaterials, and Nanomedicine, CIBER-BBN, SLFPB-EHU, 01006 Vitoria-Gasteiz, Spain.

Trends in Pharmacological Sciences
|June 13, 2015
PubMed
Summary
This summary is machine-generated.

Implantable living cellular systems offer precise, continuous drug delivery for chronic diseases, overcoming limitations of current pharmaceutical therapies. This advanced cell encapsulation technology paves the way for future therapeutic innovations.

Keywords:
alginateallograftscell transplantationdrug deliverymicrocapsules

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Drug Delivery Systems

Background:

  • Chronic diseases require precise, continuous therapeutic molecule regulation, which is often unachievable with conventional pharmaceutical therapies.
  • Implantable living cellular systems offer a potential solution for sustained drug delivery, matching treatment duration with disease longevity.

Purpose of the Study:

  • To discuss the next generation of clinical trials and potential approaches for cell encapsulation technologies.
  • To explore advancements in 'smart' and responsive encapsulation systems, sophisticated devices, and novel imaging tools.

Main Methods:

  • Discusses advancements in cell encapsulation technology.
  • Reviews next-generation clinical trials and potential therapeutic approaches.
  • Highlights the integration of biomaterials and cellular systems.

Main Results:

  • Cell encapsulation is a viable therapeutic option for chronic diseases.
  • The field is progressing towards previously unattainable therapeutic domains.
  • Next-generation strategies include responsive systems, multifunctional devices, and advanced imaging.

Conclusions:

  • Cell encapsulation technology holds significant promise for treating chronic diseases.
  • Future directions involve developing 'smart' systems, sophisticated devices, and improved imaging.
  • Overcoming interdisciplinary challenges is crucial for clinical translation.