Related Experiment Video
Updated: Apr 10, 2026

Novel Percutaneous Approach for Deployment of 3D Printed Coronary Stenosis Implants in Swine Models of Ischemic Heart Disease
Published on: February 18, 2020
Self-expandable CoreValve implantation without contrast media.
Giuseppe Bruschi1, Paola Colombo2, Federico De Marco2
1Department of Cardiology and Cardiac Surgery, A. De Gasperis Niguarda Ca' Granda Hospital, Milan, Italy giuseppe.bruschi@fastwebnet.it.
This study presents a novel approach for transcatheter aortic valve implantation (TAVI) without contrast media, specifically for patients with severe aortic stenosis and chronic kidney disease. This technique reduces the risk of acute kidney injury in high-risk patients undergoing this critical procedure.
Area of Science:
- Cardiology
- Nephrology
- Medical Imaging
Background:
- Severe aortic stenosis often affects patients with chronic kidney disease (CKD).
- Standard transcatheter aortic valve implantation (TAVI) requires contrast media, increasing acute kidney injury (AKI) risk in CKD patients.
- High-risk patients with end-stage CKD pose a significant challenge for TAVI procedures.
Observation:
- A case study of an 80-year-old male with severe aortic stenosis and end-stage CKD was presented.
- The patient underwent a self-expandable TAVI procedure.
- The procedure was successfully performed without the use of any contrast media.
Findings:
- Self-expandable TAVI is feasible without contrast media in patients with end-stage CKD.
- Eliminating contrast media during TAVI mitigates the risk of contrast-induced nephropathy.
- The procedure demonstrated successful valve deployment and functional improvement.
Implications:
- This contrast-sparing technique offers a safer alternative for TAVI in patients with severe renal impairment.
- It expands treatment options for high-risk patients with comorbid CKD.
- Further research into contrast-sparing TAVI techniques is warranted to improve patient outcomes.
Related Concept Videos
Heart Valves
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Mitral Valve Prolapse I: Introduction
Cardiac Catheterization III: Left Heart Catheterization
Aortic Regurgitation I: Introduction
Mitral Regurgitation I: Introduction
Cardiac Catheterization II: Right Heart Catheterization

