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Mouse Breeding and Colony Management
Abdelkader Ayadi1, Gisèle Ferrand2, Isabelle Goncalves da Cruz1
1Institut Clinique de la Souris (ICS), Illkirch, France.
Current Protocols in Mouse Biology
|June 13, 2015
Summary
Efficiently managing genetically engineered mouse models (GEMMs) requires understanding mouse reproduction and controlling environmental factors. This ensures optimal breeding for research facility needs.
Area of Science:
- Genetics
- Animal Models
- Reproductive Biology
Background:
- Genetically engineered mouse models (GEMMs) are crucial research tools.
- Increased GEMM creation leads to higher demand for research facility housing.
- Effective colony management is essential for populating research facilities.
Purpose of the Study:
- To provide knowledge on mouse reproduction for efficient GEMM colony management.
- To outline methods for handling and breeding GEMMs.
- To address challenges in breeding difficult GEMM lines.
Main Methods:
- Controlling environmental parameters (e.g., diet, temperature, light).
- Implementing proper animal identification and genotyping.
- Utilizing various mating types and breeding schemes.
- Employing assisted reproduction techniques for challenging lines.
Main Results:
- Mouse reproduction is influenced by environmental factors, necessitating tight control.
- Efficient management involves meticulous record-keeping and animal tracking.
- Diverse breeding strategies can be applied based on study requirements.
- Assisted reproduction methods offer solutions for breeding difficulties.
Conclusions:
- Understanding mouse reproductive biology is key for effective GEMM colony management.
- Optimizing environmental conditions and management practices enhances breeding efficiency.
- Assisted reproduction methods are valuable for overcoming breeding challenges in GEMMs.
