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Anti-neutrophil cytoplasmic antibody vasculitis presenting with bilateral renal vein thrombosis

Christina Wlodek1, Michael Gregory Robson1

  • 1Department of Nephrology and Transplantation, Guy's and St. Thomas' NHS Foundation Trust, London, UK.

Clinical Kidney Journal
|June 13, 2015
PubMed

We report a case of anti-neutrophil cytoplasmic antibody (ANCA)-associated necrotizing crescentic glomerulonephritis presenting with bilateral renal vein thrombosis and pulmonary emboli in a patient who also had a lupus anticoagulant and anti-cardiolipin antibodies. Although the link between venous thrombosis and ANCA vasculitis is well established, the coexistence of renal vein thrombosis is unusual. Furthermore, despite the positive ANCA, he was initially negative for antibodies to myeloperoxidase (MPO) and proteinase-3 (PR3), illustrating that a positive ANCA may be significant despite a negative test for antibodies to MPO and PR3.

Keywords:
ANCAanti-phospholipidcrescentic glomerulonephritisrenal vein thrombosis

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