Related Experiment Video

Updated: Apr 10, 2026

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.7K

Sirtuin Functions in Female Fertility: Possible Role in Oxidative Stress and Aging

Carla Tatone1, Giovanna Di Emidio2, Maurizio Vitti2

  • 1Department of Life, Health and Environmental Sciences, University of L'Aquila, Via Vetoio, 67100 L'Aquila, Italy ; Infertility Service, San Salvatore Hospital, Via Vetoio, 67100 L'Aquila, Italy.

Oxidative Medicine and Cellular Longevity
|June 16, 2015
PubMed

Insights

Sirtuins, key antiaging enzymes, are vital for female fertility by protecting oocytes from oxidative stress. Impaired SIRT1 signaling contributes to oocyte aging, highlighting sirtuins as targets for fertility preservation.

Area of Science:

  • Reproductive biology
  • Molecular biology
  • Gerontology

Background:

  • Sirtuins (silent information regulator 2 proteins) are NAD(+)-dependent enzymes with deacetylase and/or mono-ADP-ribosyltransferase activity.
  • They are recognized as crucial antiaging molecules and regulators in various diseases.
  • SIRT1 and SIRT3 are key sirtuin family members involved in sensing and maintaining redox balance in female reproductive cells.

Purpose of the Study:

  • To review current research on the role of sirtuins in female fertility.
  • To emphasize the impact of impaired SIRT1 signaling on oocyte aging.
  • To propose a framework for future research on sirtuins for female fertility preservation.

Main Methods:

  • Literature review of research papers on sirtuins and female fertility.
  • Focus on studies investigating SIRT1 signaling and its role in oocyte aging.
  • Analysis of the redox-protective functions of sirtuins in reproductive contexts.

Main Results:

  • Sirtuins, particularly SIRT1 and SIRT3, play a critical role in protecting oocytes, granulosa cells, and early embryos from oxidative damage.
  • Impairment of SIRT1 signaling is linked to the aging of oocytes, negatively affecting female fertility.
  • Evidence suggests sirtuins are essential guardians of the female reproductive system's redox state.

Conclusions:

  • Sirtuins are crucial for maintaining female fertility by mitigating oxidative stress.
  • SIRT1 dysfunction is a significant factor in age-related decline in oocyte quality.
  • Targeting sirtuins offers a promising avenue for developing strategies to preserve female fertility.

More Related Videos

Measurements of Physiological Stress Responses in C. Elegans10:36

Measurements of Physiological Stress Responses in C. Elegans

Published on: May 21, 2020

15.3K
Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates

Published on: February 27, 2016

8.8K

Related Concept Videos

Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
1.0K
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
21.5K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.1K
Meiosis I03:09

Meiosis I

Meiosis is the division of a diploid cell into haploid cells forming sperm and eggs in animals through differentiation. Meiosis I is the first stage of meiosis, where the genetic recombination of homologous chromosomes and the reduction of the ploidy level by half occurs.
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
46.7K
Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
71.5K
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.6K