Related Experiment Video

Updated: Apr 10, 2026

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

10.9K

Retrospective Evaluation of New Chinese Diagnostic Scoring System for Disseminated Intravascular Coagulation

Manzhi Wang1, Haiming Kou1, Jun Deng1

  • 1Institute of Hematology, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.

Plos One
|June 16, 2015
PubMed

Insights

The new Chinese DIC scoring system (CDSS) demonstrates good diagnostic accuracy and prognostic value for disseminated intravascular coagulation (DIC). This validated system shows promise in clinical settings for identifying DIC patients.

Area of Science:

  • Hematology
  • Clinical Diagnostics
  • Medical Informatics

Background:

  • Disseminated intravascular coagulation (DIC) is a complex syndrome requiring accurate diagnostic tools.
  • Existing scoring systems for DIC have limitations, necessitating novel approaches.

Purpose of the Study:

  • To retrospectively validate the newly developed Chinese DIC scoring system (CDSS).
  • To compare the performance of CDSS against established international scoring systems.
  • To evaluate the prognostic capability of CDSS in predicting patient outcomes.

Main Methods:

  • Retrospective analysis of 619 patients suspected of DIC (non-hematologic and hematologic malignancies).
  • Validation of CDSS against ISTH, JAAM, and JMHW scoring systems.
  • Assessment of prognostic value using 28-day mortality, APACHE II, and SOFA scores.

Main Results:

  • CDSS showed higher specificity than JAAM and higher sensitivity than ISTH in non-hematologic malignancies.
  • CDSS demonstrated superior diagnostic performance (AUC) compared to ISTH and JMHW in hematologic malignancies.
  • CDSS-diagnosed DIC patients had significantly higher 28-day mortality, SOFA, and APACHE II scores.

Conclusions:

  • CDSS is the first proposed system emphasizing clinical signs, platelet count, APTT, and D-dimer for DIC diagnosis.
  • The system accounts for DIC in hematologic malignancies as a distinct category.
  • CDSS exhibits acceptable sensitivity and specificity for DIC diagnosis with good prognostic value.
Abstract

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
905
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
461
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
441