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Updated: Apr 10, 2026
Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Glycine-Linked Nucleoside-β-Amino Acids: Polyamide Analogues of Nucleic Acids
Anjan Banerjee1, Seema Bagmare1, Manojkumar Varada1
1Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune, India 411008.
Abstract:
3'-5'-Deoxyribose-sugar-phoshate backbone in DNA is completely replaced by 2'-deoxyribonucleoside-based β-amino acids interlinked by glycine to create uncharged polyamide DNA with 3'-5'-directionality. These oligomers as conjugates of α-amino acids and nucleoside-β-amino acids bind strongly and sequence-specifically only to the antiparallel complementary RNA and DNA.
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