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Updated: Apr 10, 2026
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Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
16.8K
Cell therapy for immunosuppression after kidney transplantation
Christian Morath1, Anita Schmitt, Martin Zeier
1Division of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120, Heidelberg, Germany, christian.morath@med.uni-heidelberg.de.
Langenbeck'S Archives of Surgery
|June 17, 2015
Summary
Cellular therapies, including myeloid suppressor cell therapy (MICs), are emerging as novel approaches to achieve immunosuppression and donor-specific unresponsiveness in kidney transplantation. These innovative treatments show promise for revolutionizing the field.
Area of Science:
- Immunology
- Transplantation Science
- Cell Therapy
Background:
- Kidney transplantation requires lifelong immunosuppression to prevent rejection.
- Current immunosuppressive strategies carry significant side effects and limitations.
- Cellular therapies offer a promising alternative for achieving donor-specific unresponsiveness.
Purpose of the Study:
- To review cell therapeutic approaches for immunosuppression in kidney transplantation.
- To highlight myeloid suppressor cell therapy using mitomycin C-induced cells (MICs).
Main Methods:
- Literature review focusing on existing cell therapy trials.
- Analysis of different cell product types (regulatory T cells, macrophages, myeloid suppressor cells).
Main Results:
- Multiple cell therapies are in early clinical trials for kidney transplantation.
- Challenges include identifying and expanding sufficient numbers of suppressive cells.
- Mitomycin C-induced cell (MIC) therapy presents a simple, safe method for donor unresponsiveness in living-donor kidney transplants.
- A Phase I trial is evaluating MIC therapy's safety and efficacy.
Conclusions:
- Cellular therapies have the potential to transform immunosuppression strategies in kidney transplantation.
- MIC therapy is a promising approach for inducing donor-specific unresponsiveness.
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