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Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

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Olanzapine-Induced Reversible Pellagroid Skin Lesion.

Lokesh K Singh, Manoj Sahu, Samir K Praharaj¹

¹Department of Psychiatry, Kasturba Medical College, Manipal, Karnataka, 576104, India. samirpsyche@yahoo.co.in.

Current Drug Safety

|June 17, 2015

Summary

Adverse skin reactions to psychotropic drugs can reduce compliance. This case study highlights rare pellagroid skin lesions caused by olanzapine, which resolved after discontinuing the atypical antipsychotic.

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Area of Science:

Dermatology
Psychiatry
Pharmacology

Background:

Adverse cutaneous reactions (ACRs) are common with psychotropic medications, impacting patient compliance.
Antipsychotics, particularly atypical ones, are less frequently associated with ACRs compared to other psychotropic classes.
Common ACRs with antipsychotics include fixed drug eruptions, exanthematous eruptions, photosensitivity, and altered skin pigmentation.

Observation:

Olanzapine, a widely used atypical antipsychotic, is known for metabolic complications but rarely causes dermatological reactions.
A patient developed pellagroid skin lesions on exposed upper limbs while taking olanzapine.
These skin lesions resolved completely upon discontinuation of olanzapine therapy.

Findings:

This case presents a rare dermatological adverse effect of olanzapine, specifically pellagroid skin lesions.
The reaction was localized to sun-exposed areas, suggesting a potential photosensitive or irritant component.
Complete resolution after drug cessation confirms olanzapine as the likely causative agent.

Implications:

Clinicians should be aware of rare dermatological side effects of olanzapine, even if generally considered safe.
Prompt recognition and discontinuation of the offending agent are crucial for managing such reactions.
Further investigation may be warranted to understand the mechanism of olanzapine-induced pellagroid reactions.