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Updated: Apr 10, 2026

A Novel Clinical Grade Isolation Method for Human Kidney Perivascular Stromal Cells
Published on: August 7, 2017
Cell-based therapy for kidney disease
Hyun Chul Chung1, In Kap Ko2, Anthony Atala2
1Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA. ; Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea.
Abstract:
The prevalence of renal disease continues to increase worldwide. When normal kidney is injured, the damaged renal tissue undergoes pathological and physiological events that lead to acute and chronic kidney diseases, which frequently progress to end stage renal failure. Current treatment of these renal pathologies includes dialysis, which is incapable of restoring full renal function. To address this issue, cell-based therapy has become a potential therapeutic option to treat renal pathologies. Recent development in cell therapy has demonstrated promising therapeutic outcomes, in terms of restoration of renal structure and function impaired by renal disease. This review focuses on the cell therapy approaches for the treatment of kidney diseases, including various cell sources used, as well recent advances made in preclinical and clinical studies.
Insights
Cell therapy offers a promising approach to treat kidney diseases, potentially restoring renal structure and function. This review explores various cell sources and recent advancements in cell-based treatments for renal pathologies.
Area of Science:
- Nephrology
- Regenerative Medicine
- Biotechnology
Background:
- Global prevalence of kidney disease is rising, leading to end-stage renal failure.
- Current treatments like dialysis cannot fully restore kidney function.
- Cell-based therapy presents a potential therapeutic strategy for renal pathologies.
Purpose of the Study:
- To review cell therapy approaches for treating kidney diseases.
- To discuss various cell sources utilized in regenerative nephrology.
- To highlight recent advances in preclinical and clinical cell therapy studies for renal conditions.
Main Methods:
- Literature review of preclinical and clinical studies on cell therapy for kidney diseases.
- Analysis of different cell types and their therapeutic potential.
- Synthesis of recent advancements and outcomes in the field.
Main Results:
- Cell therapy has shown promising outcomes in restoring renal structure and function.
- Various cell sources are being investigated for their efficacy.
- Significant progress has been made in both preclinical and clinical research.
Conclusions:
- Cell-based therapy is a viable and evolving therapeutic option for kidney diseases.
- Further research and clinical trials are crucial to optimize treatment strategies.
- Regenerative medicine holds significant promise for managing renal pathologies.
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