Quantitative Assessment of the Association between Genetic Variants in MicroRNAs and Colorectal Cancer Risk

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Xiao-Xu Liu1, Meng Wang1, Dan Xu2

  • 1Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.

Biomed Research International
|June 17, 2015
PubMed
Abstract

Insights

This meta-analysis reveals that specific microRNA (miRNA) polymorphisms influence colorectal cancer (CRC) risk. rs2910164 and rs2292832 may increase CRC susceptibility, while rs11614913 and rs3746444 might decrease it, particularly in Caucasians.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Previous studies on microRNA (miRNA) polymorphisms and colorectal cancer (CRC) susceptibility yielded inconsistent results.
  • Investigating common miRNA polymorphisms (hsa-mir-146a rs2910164, hsa-mir-149 rs2292832, hsa-mir-196a2 rs11614913, hsa-mir-499 rs3746444) is crucial for understanding CRC risk.

Purpose of the Study:

  • To quantitatively assess the association between four common microRNA polymorphisms and colorectal cancer risk.
  • To clarify the conflicting findings regarding miRNA gene variations and CRC susceptibility.

Main Methods:

  • A systematic literature search was conducted across PubMed, Web of Knowledge, and CNKI databases.
  • Meta-analysis was employed using odds ratios (OR) with 95% confidence intervals (95% CI) to estimate the strength of associations.
  • Fixed or random effect models were utilized based on study heterogeneity.

Main Results:

  • The meta-analysis included 15 studies with 5,486 CRC patients and 7,184 controls.
  • rs3746444 showed a significant association with decreased CRC risk in Caucasians (OR = 0.57, 95% CI = 0.34-0.95).
  • rs2910164 was associated with increased CRC risk in hospital-based studies (OR = 1.24, 95% CI = 1.03-1.49), and rs2292832 in population-based studies (OR = 1.18, 95% CI = 1.08-1.38).

Conclusions:

  • The microRNA polymorphisms rs2910164 and rs2292832 may be linked to an increased risk of colorectal cancer.
  • Conversely, the rs11614913 polymorphism might be associated with a reduced risk of CRC.
  • rs3746444 appears to confer a protective effect against CRC, particularly in Caucasian populations.

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