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Updated: Apr 10, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Intramolecular [2 + 2] Photodimerization Achieved in the Solid State via Coordination-Driven Self-Assembly
Rebecca C Laird1, Michael A Sinnwell1, Nam P Nguyen1
1Department of Chemistry, University of Iowa, Iowa City, Iowa 52242-1294, United States.
Abstract:
An intramolecular [2 + 2] photocycloaddition is achieved in the organic solid state via self-assembly of Ag(I) ions and an endo-ditopic bipyridine. The cations aide to organize carbon-carbon double (C═C) bonds attached to the bipyridine for the cycloaddition reaction. The C═C bonds react regioselectively and quantitatively to afford a photoproduct with edge-sharing four-, five-, and six-membered rings. Our study demonstrates the first use of a metal-organic template to direct an intramolecular [2 + 2] photodimerization in the organic solid state.
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