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Updated: Apr 10, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
Presentation of multiple sclerosis with comorbid Huntington's disease
Heidi W Maloni1, Mitchell T Wallin2
1Neurology Service, Department of Veterans Affairs (VA) Medical Center, Washington, DC, USA; VA Multiple Sclerosis Centers of Excellence, USA.
Abstract:
We report a case of Huntington's disease (HD) in a 53-year-old male with multiple sclerosis (MS). The diagnosis of MS met the McDonald criteria and was based on clinical attacks separated in space and time, cerebrospinal fluid, and MRI. The diagnosis of HD was established by DNA testing, family history, and positron emission tomography. While a number of neurologic and autoimmune diseases have been reported with MS, this is the first co-occurrence of HD and MS. Salient features of both disorders are reviewed as well as the importance of obtaining a thorough family history.
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