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A Multiscale Tridomain Model for Simulating Bioelectric Gastric Pacing.

Shameer Sathar, Mark L Trew, Greg OGrady

IEEE Transactions on Bio-Medical Engineering

|June 17, 2015

Summary

This study developed a 3-D stomach model to test gastric pacing for motility disorders. The new model is more efficient and aids in designing effective, power-efficient pacing protocols for gastric dysrhythmias.

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Area of Science:

Computational biology
Biomedical engineering
Gastroenterology

Background:

Gastric motility disorders are linked to abnormal gastric electrical activity (gastric dysrhythmias).
Gastric pacing offers a potential therapy, but requires optimized, power-efficient protocols.

Purpose of the Study:

To present a novel, comprehensive 3-D multiscale modeling framework of the human stomach.
To evaluate novel gastric pacing strategies for efficacy and power efficiency.

Main Methods:

Anatomically realistic 3-D stomach mesh generated from CT scans.
Incorporation of anisotropic conduction using a modified Laplace-Dirichlet algorithm.
Implementation of a continuum-based tridomain formulation to model slow-wave propagation in gastric musculature.

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Main Results:

The novel formulation demonstrated twofold efficiency improvement over previous methods for slow-wave simulation.
Convergence analysis indicated a mesh resolution of [Formula: see text] is necessary for accurate simulations.
Simulations of external pacing successfully entrained slow-wave patterns.

Conclusions:

Pacing protocols' effectiveness is constrained by native propagation frequency and cellular refractory periods.
The developed model is a valuable tool for optimizing gastric pacing strategies for efficiency and effectiveness.