SUBCHRONIC MANCOZEB TREATEMENT INDUCED LIVER TOXICITY VIA OXIDATIVE STRESS IN MALE WISTAR RATS

Area of Science:

• Environmental toxicology
• Biochemistry
• Animal physiology

Background:

• Mancozeb is a widely used agricultural fungicide.
• Its impact on animal health, particularly oxidative stress and biochemical markers, requires investigation.

Purpose of the Study:

• To evaluate the effects of mancozeb on oxidative stress and biochemical parameters in male Wistar rats.
• To determine potential hepatotoxic effects and associated health risks.

Main Methods:

• Adult male Wistar rats were administered two doses of mancozeb (800 and 1200 mg/kg/day) orally for 4 weeks.
• Levels of reduced glutathione (GSH) and activities of liver enzymes (AST, ALT, ALP) were measured.
• Liver fresh weight was also assessed.

Main Results:

• Mancozeb treatment significantly decreased reduced glutathione (GSH) levels.
• A significant increase in liver fresh weight was observed in treated rats.
• Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels decreased, while alkaline phosphatase (ALP) activity increased significantly.

Conclusions:

• Mancozeb exposure induces significant oxidative stress and hepatotoxicity in rats.
• Altered biochemical markers suggest liver damage.
• These findings highlight potential environmental health risks posed by mancozeb.